バイオインフォマティクス、ケモインフォマティクス、臨床研究、機械学習をカバーする125以上の科学スキル。
A comprehensive collection of 140+ ready-to-use scientific and research skills for any AI agent that supports the open Agent Skills standard, created by K-Dense. Works with Cursor, Claude Code, Codex, and more. Transform your AI agent into a research assistant capable of executing complex multi-step scientific workflows across biology, chemistry, medicine, and beyond.
Looking for the full AI co-scientist experience? Try K-Dense Web for 200+ skills, cloud compute, and publication-ready outputs.
Want 10x the power with zero setup? K-Dense Web is the complete AI co-scientist platform—everything in this repo, plus:
| Feature | This Repo | K-Dense Web |
|---|---|---|
| Scientific Skills | 140 skills | 200+ skills (exclusive access) |
| Setup Required | Manual installation | Zero setup — works instantly |
| Compute | Your machine | Cloud GPUs & HPC included |
| Workflows | Basic prompts | End-to-end research pipelines |
| Outputs | Code & analysis | Publication-ready figures, reports & papers |
| Integrations | Local tools | Lab systems, ELNs, cloud storage |
Researchers at Stanford, MIT, and leading pharma companies use K-Dense Web to accelerate discoveries.
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These skills enable your AI agent to seamlessly work with specialized scientific libraries, databases, and tools across multiple scientific domains:
Transform your AI coding agent into an 'AI Scientist' on your desktop!
⭐ If you find this repository useful, please consider giving it a star! It helps others discover these tools and encourages us to continue maintaining and expanding this collection.
🎬 New to Claude Scientific Skills? Watch our Getting Started with Claude Scientific Skills video for a quick walkthrough.
This repository provides 140 scientific skills organized into the following categories:
Each skill includes:
SKILL.md)Claude Scientific Skills follows the open Agent Skills standard. Simply copy the skill folders into your skills directory and your AI agent will automatically discover and use them.
git clone https://github.com/K-Dense-AI/claude-scientific-skills.git
Copy the individual skill folders from scientific-skills/ to one of the supported skill directories below. You can install skills globally (available across all projects) or per-project (available only in that project).
Global installation (recommended — skills available everywhere):
| Tool | Directory |
|---|---|
| Cursor | ~/.cursor/skills/ |
| Claude Code | ~/.claude/skills/ |
| Codex | ~/.codex/skills/ |
Project-level installation (skills scoped to a single project):
| Tool | Directory |
|---|---|
| Cursor | .cursor/skills/ (in your project root) |
| Claude Code | .claude/skills/ (in your project root) |
| Codex | .codex/skills/ (in your project root) |
Note: Cursor also reads from
.claude/skills/and.codex/skills/directories, and vice versa, so skills are cross-compatible between tools.
Example — global install for Cursor:
cp -r claude-scientific-skills/scientific-skills/* ~/.cursor/skills/
Example — global install for Claude Code:
cp -r claude-scientific-skills/scientific-skills/* ~/.claude/skills/
Example — project-level install:
mkdir -p .cursor/skills
cp -r /path/to/claude-scientific-skills/scientific-skills/* .cursor/skills/
That's it! Your AI agent will automatically discover the skills and use them when relevant to your scientific tasks. You can also invoke any skill manually by mentioning the skill name in your prompt.
Claude Scientific Skills is powered by 50+ incredible open source projects maintained by dedicated developers and research communities worldwide. Projects like Biopython, Scanpy, RDKit, scikit-learn, PyTorch Lightning, and many others form the foundation of these skills.
If you find value in this repository, please consider supporting the projects that make it possible:
👉 View the full list of projects to support
SKILL.md files for specific requirements)The skills use uv as the package manager for installing Python dependencies. Install it using the instructions for your operating system:
macOS and Linux:
curl -LsSf https://astral.sh/uv/install.sh | sh
Windows:
powershell -ExecutionPolicy ByPass -c "irm https://astral.sh/uv/install.ps1 | iex"
Alternative (via pip):
pip install uv
After installation, verify it works by running:
uv --version
For more installation options and details, visit the official uv documentation.
Once you've installed the skills, you can ask your AI agent to execute complex multi-step scientific workflows. Here are some example prompts:
Goal: Find novel EGFR inhibitors for lung cancer treatment
Prompt:
Use available skills you have access to whenever possible. Query ChEMBL for EGFR inhibitors (IC50 < 50nM), analyze structure-activity relationships
with RDKit, generate improved analogs with datamol, perform virtual screening with DiffDock
against AlphaFold EGFR structure, search PubMed for resistance mechanisms, check COSMIC for
mutations, and create visualizations and a comprehensive report.
Skills Used: ChEMBL, RDKit, datamol, DiffDock, AlphaFold DB, PubMed, COSMIC, scientific visualization
Goal: Comprehensive analysis of 10X Genomics data with public data integration
Prompt:
Use available skills you have access to whenever possible. Load 10X dataset with Scanpy, perform QC and doublet removal, integrate with Cellxgene
Census data, identify cell types using NCBI Gene markers, run differential expression with
PyDESeq2, infer gene regulatory networks with Arboreto, enrich pathways via Reactome/KEGG,
and identify therapeutic targets with Open Targets.
Skills Used: Scanpy, Cellxgene Census, NCBI Gene, PyDESeq2, Arboreto, Reactome, KEGG, Open Targets
Goal: Integrate RNA-seq, proteomics, and metabolomics to predict patient outcomes
Prompt:
Use available skills you have access to whenever possible. Analyze RNA-seq with PyDESeq2, process mass spec with pyOpenMS, integrate metabolites from
HMDB/Metabolomics Workbench, map proteins to pathways (UniProt/KEGG), find interactions via
STRING, correlate omics layers with statsmodels, build predictive model with scikit-learn,
and search ClinicalTrials.gov for relevant trials.
Skills Used: PyDESeq2, pyOpenMS, HMDB, Metabolomics Workbench, UniProt, KEGG, STRING, statsmodels, scikit-learn, ClinicalTrials.gov
Goal: Discover allosteric modulators for protein-protein interactions
Prompt:
Use available skills you have access to whenever possible. Retrieve AlphaFold structures, identify interaction interface with BioPython, search ZINC
for allosteric candidates (MW 300-500, logP 2-4), filter with RDKit, dock with DiffDock,
rank with DeepChem, check PubChem suppliers, search USPTO patents, and optimize leads with
MedChem/molfeat.
Skills Used: AlphaFold DB, BioPython, ZINC, RDKit, DiffDock, DeepChem, PubChem, USPTO, MedChem, molfeat
Goal: Analyze VCF file for hereditary cancer risk assessment
Prompt:
Use available skills you have access to whenever possible. Parse VCF with pysam, annotate variants with Ensembl VEP, query ClinVar for pathogenicity,
check COSMIC for cancer mutations, retrieve gene info from NCBI Gene, analyze protein impact
with UniProt, search PubMed for case reports, check ClinPGx for pharmacogenomics, generate
clinical report with document processing tools, and find matching trials on ClinicalTrials.gov.
Skills Used: pysam, Ensembl, ClinVar, COSMIC, NCBI Gene, UniProt, PubMed, ClinPGx, Document Skills, ClinicalTrials.gov
Goal: Analyze gene regulatory networks from RNA-seq data
Prompt:
Use available skills you have access to whenever possible. Query NCBI Gene for annotations, retrieve sequences from UniProt, identify interactions via
STRING, map to Reactome/KEGG pathways, analyze topology with Torch Geometric, reconstruct
GRNs with Arboreto, assess druggability with Open Targets, model with PyMC, visualize
networks, and search GEO for similar patterns.
Skills Used: NCBI Gene, UniProt, STRING, Reactome, KEGG, Torch Geometric, Arboreto, Open Targets, PyMC, GEO
📖 Want more examples? Check out docs/examples.md for comprehensive workflow examples and detailed use cases across all scientific domains.
This repository contains 140 scientific skills organized across multiple domains. Each skill provides comprehensive documentation, code examples, and best practices for working with scientific libraries, databases, and tools.
📖 For complete details on all skills, see docs/scientific-skills.md
💡 Looking for practical examples? Check out docs/examples.md for comprehensive workflow examples across all scientific domains.
We welcome contributions to expand and improve this scientific skills repository!
✨ Add New Skills
📚 Improve Existing Skills
🐛 Report Issues
git checkout -b feature/amazing-skill)SKILL.md filesgit commit -m 'Add amazing skill')git push origin feature/amazing-skill)✅ Adhere to the Agent Skills Specification — Every skill must follow the official spec (valid SKILL.md frontmatter, naming conventions, directory structure)
✅ Maintain consistency with existing skill documentation format
✅ Ensure all code examples are tested and functional
✅ Follow scientific best practices in examples and workflows
✅ Update relevant documentation when adding new capabilities
✅ Provide clear comments and docstrings in code
✅ Include references to official documentation
Contributors are recognized in our community and may be featured in:
Your contributions help make scientific computing more accessible and enable researchers to leverage AI tools more effectively!
This project builds on 50+ amazing open source projects. If you find value in these skills, please consider supporting the projects we depend on.
Problem: Skills not loading
SKILL.md fileProblem: Missing Python dependencies
SKILL.md file for required packagesuv pip install package-nameProblem: API rate limits
Problem: Authentication errors
SKILL.md for authentication setupProblem: Outdated examples
Q: Is this free to use?
A: Yes! This repository is MIT licensed. However, each individual skill has its own license specified in the license metadata field within its SKILL.md file—be sure to review and comply with those terms.
Q: Why are all skills grouped together instead of separate packages?
A: We believe good science in the age of AI is inherently interdisciplinary. Bundling all skills together makes it trivial for you (and your agent) to bridge across fields—e.g., combining genomics, cheminformatics, clinical data, and machine learning in one workflow—without worrying about which individual skills to install or wire together.
Q: Can I use this for commercial projects?
A: The repository itself is MIT licensed, which allows commercial use. However, individual skills may have different licenses—check the license field in each skill's SKILL.md file to ensure compliance with your intended use.
Q: Do all skills have the same license?
A: No. Each skill has its own license specified in the license metadata field within its SKILL.md file. These licenses may differ from the repository's MIT License. Users are responsible for reviewing and adhering to the license terms of each individual skill they use.
Q: How often is this updated?
A: We regularly update skills to reflect the latest versions of packages and APIs. Major updates are announced in release notes.
Q: Can I use this with other AI models?
A: The skills follow the open Agent Skills standard and work with any compatible agent, including Cursor, Claude Code, and Codex.
Q: Do I need all the Python packages installed?
A: No! Only install the packages you need. Each skill specifies its requirements in its SKILL.md file.
Q: What if a skill doesn't work?
A: First check the Troubleshooting section. If the issue persists, file an issue on GitHub with detailed reproduction steps.
Q: Do the skills work offline?
A: Database skills require internet access to query APIs. Package skills work offline once Python dependencies are installed.
Q: Can I contribute my own skills?
A: Absolutely! We welcome contributions. See the Contributing section for guidelines and best practices.
Q: How do I report bugs or suggest features?
A: Open an issue on GitHub with a clear description. For bugs, include reproduction steps and expected vs actual behavior.
Need help? Here's how to get support:
SKILL.md and references/ foldersWe'd love to have you join us! 🚀
Connect with other scientists, researchers, and AI enthusiasts using AI agents for scientific computing. Share your discoveries, ask questions, get help with your projects, and collaborate with the community!
Whether you're just getting started or you're a power user, our community is here to support you. We share tips, troubleshoot issues together, showcase cool projects, and discuss the latest developments in AI-powered scientific research.
See you there! 💬
If you use Claude Scientific Skills in your research or project, please cite it as:
@software{claude_scientific_skills_2026,
author = {{K-Dense Inc.}},
title = {Claude Scientific Skills: A Comprehensive Collection of Scientific Tools for Claude AI},
year = {2026},
url = {https://github.com/K-Dense-AI/claude-scientific-skills},
note = {skills covering databases, packages, integrations, and analysis tools}
}
K-Dense Inc. (2026). Claude Scientific Skills: A comprehensive collection of scientific tools for Claude AI [Computer software]. https://github.com/K-Dense-AI/claude-scientific-skills
K-Dense Inc. Claude Scientific Skills: A Comprehensive Collection of Scientific Tools for Claude AI. 2026, github.com/K-Dense-AI/claude-scientific-skills.
Claude Scientific Skills by K-Dense Inc. (2026)
Available at: https://github.com/K-Dense-AI/claude-scientific-skills
We appreciate acknowledgment in publications, presentations, or projects that benefit from these skills!
This project is licensed under the MIT License.
Copyright © 2026 K-Dense Inc. (k-dense.ai)
See LICENSE.md for full terms.
⚠️ Important: Each skill has its own license specified in the
licensemetadata field within itsSKILL.mdfile. These licenses may differ from the repository's MIT License and may include additional terms or restrictions. Users are responsible for reviewing and adhering to the license terms of each individual skill they use.
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